Inhibition of HIV virus-like particles production by BST-2.
- Author:
Ying-Lian DU
1
;
Si-Qi HU
;
Xiao-Jing PANG
;
Shan CEN
;
Qi JIN
;
Fei GUO
Author Information
1. State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, CD;
genetics;
metabolism;
Cell Line;
Cercopithecus aethiops;
Down-Regulation;
GPI-Linked Proteins;
genetics;
metabolism;
HIV Infections;
genetics;
metabolism;
virology;
HIV-1;
genetics;
physiology;
Humans;
Vero Cells;
Virion;
genetics;
physiology;
Virus Replication
- From:
Chinese Journal of Virology
2011;27(4):319-325
- CountryChina
- Language:Chinese
-
Abstract:
Recently, BST-2 has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1 and other enveloped viruses by tethering virus particles to the cell surface. Here, we showed that the production of HIV-1 virus-like particles was markedly inhibited by BST-2. Both the transient and stable expressing of BST-2 had the same function and Vpu rescued the release of HIV-1 VLP in the presence of human BST-2. Consistent with a direct tethering mechanism, we confirmed that proteolysis releases restricted virions and further showed that this removed the ectodomain of BST-2 from the cell surface.
