Morphological study on early development of brain derived neurophic factor-positive neurons in the frontal lobe of human fetus.
- Author:
Lan-rong ZHENG
1
;
Xiao-qun ZHU
;
Xiao-mei HUANG
;
Qian GU
;
Dong-hui XIE
Author Information
- Publication Type:Journal Article
- MeSH: Brain-Derived Neurotrophic Factor; metabolism; Fetus; metabolism; Frontal Lobe; embryology; Humans; Neurons; cytology; metabolism
- From: Acta Academiae Medicinae Sinicae 2013;35(3):260-264
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the growth and development of brain derived neurophic factor(BDNF)-positive neurons in the frontal lobe of human fetus.
METHODSThe expression of the BDNF-positive neurons in the frontal lobe of human fetus in the 2(nd),3(rd),and 4(th) month of gestation were observed with the streptavidin-biotin-complex/immunoperoxidase(SABC)method.
RESULTSBy the second month of gestation,BDNF-positive neurons were seen in the subventricular layer of the frontal lobe of cerebellum.By the third month of gestation,BDNF-positive neurons in the central layer were in various shapes,with big nucleus,less cytoplasm,and small processes.By the fourth month of gestation,BDNF-positive neurons in the central layer grew larger in size,cytoplasm increased,the BDNF-positive expression was enhanced with deeper dyeing,and the nerve fibers and particles were distributed between neurons;also,the BDNF-positive neurons were seen in the marginal layer of the frontal lobe of cerebrum.
CONCLUSIONBDNF-positive neurons may participate in the early development of the frontal lobe of cerebrum of human fetus.
