Relationship between the G protein gated inward rectifier potassium channel 4 gene polymorphism and dyslipidemia of Uyghur residents.
- Author:
Dan SHAO
1
;
Nan-fang LI
2
;
Yan-rong HU
2
;
De-lian ZHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Dyslipidemias; epidemiology; metabolism; Genotype; Humans; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; genetics; Triglycerides
- From: Acta Academiae Medicinae Sinicae 2013;35(6):611-617
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the G protein-gated inward rectifier K+ channel subunit 4 (GIRK4) gene polymorphism and the dyslipidemia among Uyghur residents in Xinjiang.
METHODSThe polymorphisms of rs2604204, rs4937391, rs6590357, and rs11221497 among the Uyghur residents were genotyped using Taqman polymerase chain reaction (PCR). Lipid levels were measured by conventional methods and were analyzed.
RESULTSIn the less-than-50-years population, the genotype distributions of the rs6590357 was statistically significant different in subjects with or without abnormal triglycerides (P=0.005). Aslo, the the genotype distributions of the rs11221497 also significantly differed in subjects with normal compared or abnormal TG (P=0.011). Logistic regression analysis suggested that rs6590357 still had positive association with TG abnormalities in subjects under 50 years (P=0.014). rs11221497 also had positive association with TC abnormalities. The TG levels of CT+TT genotypes were significantly higher than the CC group (P=0.006). Haplotype analysis found that the differences of H3 haplotype frequencies between the TG abnormal and normal groups were statistically significant (P=0.007).
CONCLUSIONThe polymorphisms of rs11221497 and rs6590357 of GIRK4 gene may play a role in the development of dyslipidemia in Uygur population.
