Efficacy and safety of combination of sorafenib and transarterial chemoembolization in treating primary hepatocellular carcinoma.
- Author:
Lu-feng CHEN
1
;
Hong-ying SU
1
;
Ke XU
1
;
Hai-bo SHAO
1
;
Song-nian LIANG
1
;
Jing LIU
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; therapeutic use; Carcinoma, Hepatocellular; therapy; Chemoembolization, Therapeutic; Female; Humans; Liver Neoplasms; therapy; Male; Middle Aged; Niacinamide; analogs & derivatives; therapeutic use; Phenylurea Compounds; therapeutic use; Retrospective Studies; Treatment Outcome
- From: Acta Academiae Medicinae Sinicae 2014;36(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of the combination of sorafenib and transarterial chemoembolization (TACE)in the treatment of primary hepatocellular carcinoma (HCC).
METHODSThe clinical data of 10 patients with unresectable HCC treated by sorafenib combined with TACE in the Department of Radiology, the First Hospital of China Medical University were retrospectively analyzed. The efficacy was evaluated according to the modified Response Evaluation Criteria in Solid Tumors assessment. Survival was analyzed by Kaplan-Meier method. Safety was evaluated according to the National Cancer Institute Common Toxicity Criteria for Adverse Events version 3.0.
RESULTSAmong the 10 patients, 2 achieved complete response, 3 achieved partial response, 3 achieved stable disease, and 2 experienced progressive disease. The median overall survival of the cohort was 29.5 months. Different degree of adverse drug reactions (ADRs) occurred in 9 patients but all were at grade 3 or lower. The most common ADRs were hand-foot skin reaction (7/10) and diarrhea (6/10).
CONCLUSIONThe combination of sorafenib and TACE is an effective and safe treatment for HCC.
