- Author:
Min CHEN
1
;
Xian XU
1
;
Shao-jun HAN
1
;
Yan-hua TANG
1
;
Jun ZHANG
1
;
Tian-ming DONG
1
;
Pan-li ZUO
2
;
Ning-yu AN
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cartilage, Articular; injuries; surgery; Cell Transplantation; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged
- From: Acta Academiae Medicinae Sinicae 2014;36(1):86-91
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of T2 mapping in monitoring the repaired cartilage after matrix-associated autologous chondrocyte implantation/transplantation (MACI/MACT).
METHODSFour patients (10 plug cartilages) were examined three times by T2 mapping at 1, 3, and 6 months using a 3.0 Tesla MR scan system. Quantitative mean (full-thickness) T2 values were calculated in the transplanted area and control cartilage. Paired t-tests were used to compare the T2 values between transplanted and control cartilage. For analysis of longitudinal T2 values, one-way analyses of variance were performed among 1, 3, and 6 months after MACI.
RESULTSThe mean T2 values of the transplanted area at 1, 3, and 6 months after MACI were (82.40±15.23), (71.09±13.06), (53.80±4.86) ms, respectively. There were significant differences between the transplanted and control cartilage at 1 and 3 months (both P<0.01) after MACI, but not at 6 months (P=0.196). There were significant differences among T2 values of 1, 3, and 6 months after MACI in transplanted area (P=0.03).
CONCLUSIONT2 mapping provides a useful tool for monitoring the biochemical development of the transplanted cartilage and can be used to evaluate the cartilage repair noninvasively.