Single centre experience of transjugular liver biopsy in 152 patients.
- Author:
Ankur PATEL
1
;
Apoorva GOGNA
;
Farah Gillan IRANI
;
Terence K B TEO
;
Tow Non YEOW
;
Deepak JAIN
;
Richard H G LO
;
Kiang Hiong TAY
;
Bien Soo TAN
;
Rafay AZHAR
;
Jason P E CHANG
;
Manish TANEJA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; methods; Female; Humans; Jugular Veins; Liver; pathology; Liver Diseases; pathology; Male; Middle Aged; Retrospective Studies; Young Adult
- From:Annals of the Academy of Medicine, Singapore 2014;43(3):160-165
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONLiver biopsy is considered the definitive investigation in the diagnosis and management of liver disease. This study describes the experience of performing transjugular liver biopsy (TJLB) over the last 9 years in a local single centre.
MATERIALS AND METHODSA retrospective review of consecutive TJLB procedures performed at our institution was conducted. A total of 152 patients (74 males and 78 females), with a mean age of 47.4 years (range, 13 to 83 years) underwent a total of 154 TJLB procedures at our institution between March 2003 and November 2011. The principal indication for TJLB was severe coagulopathy in over 80% of patients. The technical success, number of passes, histological adequacy and complication rates were analysed.
RESULTSThe procedural success rate was 98.7% (152 out of 154 procedures). Adequate material for diagnosis was obtained in 149 out of 152 (98.0%) technically successful procedures. There was procedure related morbidity in 8 patients (5.2%) of which all but one were self-limiting requiring no further intervention. We also performed hepatic venous pressure gradient (HVPG) measurements in 19% of patients at the time of TJLB.
CONCLUSIONTJLB performed at our institution is a safe and reliable technique in patients in whom traditional percutaneous liver biopsy may be hazardous. TJLB has a high technical success rate as well as a high diagnostic yield with a low complication rate. TJLB also has the added benefit of performing HVPG, which is of increasing importance in management and prognostication of chronic liver disease.