An in vitro study of anti-human cytomegalovirus effect of Forsythia suspensa and its main active ingredient quercetin.
- Author:
Dandan ZHANG
1
;
Jianguo FANG
;
Juanjuan CHEN
;
Jin WAN
;
Yawei ZHANG
;
Zongzhi YIN
;
Nan WANG
;
Suhua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; pharmacology; toxicity; Cell Line; Cytomegalovirus; drug effects; Drugs, Chinese Herbal; pharmacology; toxicity; Forsythia; chemistry; Humans; Quercetin; pharmacology; toxicity
- From: China Journal of Chinese Materia Medica 2010;35(8):1055-1059
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the in vitro anti-human cytomegalovirus effect and the cytotoxicity of Forsythia suspensa and its main active ingredient quercetin.
METHODThe 0% toxic dose (TD0), minimum effective concentration (MEC) and therapeutic index (TI) of anti-human cytomegalovirus activity by F. suspensa and quercetin were detected with the cytopathic assay and MTT method. Ganciclovir was used as the control drug for comparison.
RESULTThe TD0 of ganciclovir, F. suspensa and quercetin were 10, 30, 30 mg L(-1), the MEC were 10, 30, 0.3 mg x L(-1), TI were 1, 1 and 100, respectively.
CONCLUSIONThe anti-human cytomegalovirus effect of quercetin is much higher than ganciclovir and F. suspensa, and the cytotoxicity is equivalent to F. suspensa but lower than ganciclovir. Therefore, quercetin has the potential advantages of anti-human cytomegalovirus effect.
