Self-microemulsifying drug delivery system increasing solubility and intestinal absorption in situ of tanshinones.
- Author:
Shenghua WANG
1
;
Shan ZHAO
;
Rongping YANG
;
Guojun LV
;
Yunhong WANG
;
Weiyang XIE
;
Xiaojun MA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diterpenes, Abietane; Drug Delivery Systems; methods; Emulsions; Intestinal Absorption; drug effects; Male; Phenanthrenes; chemistry; pharmacokinetics; Rats; Rats, Sprague-Dawley; Solubility
- From: China Journal of Chinese Materia Medica 2010;35(9):1119-1122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEStudy the effect of self-microemulsifying drug delivery system(SMEDDS) on the solubility and absorption of tanshinones to guide the selection of composition of tanshinone SMEDDS.
METHODThe solubility of tanshinones in the solution of SMEDDS was determined by UV-spectrometer and the absorption of tanshinone SMEDDS was determined by HPLC as the detection method.
RESULTThe solubility of tanshinones in solution of SMEDDS was 10 times in water and 2.5 times in micelle solution. The solubility of tanshinones in solution of SMEDDS was increased with the increasing of oil (MCT) in composition of tanshinone SMEDDS. The absorption constants (Ka) in SMEDDS and micelle solution was 0.479 h(-1) and 0.326 h(-1) respectively, and the absorption half life (t1/2) was 1.44 h and 2.12 h respectively. The absorption was increased with the oil increasing in composition of tanshinone SMEDDS.
CONCLUSIONSMEDDS can increase the solubility and absorption of tanshinones significantly and the increasing of oil content (MCT) in SMEDDS composition promote the dissolution and absorption of tanshinones.
