Chemical constituents from Excoecaria acerifclia and their bioactivites.

Author: Yunzhi LI ¹ ; Chao MA ; Jing HUANG
Author Information

1. Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Anhui Agricultural University, Hefei 230036, China.
Publication Type:Journal Article
MeSH: Cell Proliferation; drug effects; Euphorbiaceae; chemistry; Hep G2 Cells; Humans; Plant Extracts; analysis; isolation & purification; pharmacology
From: China Journal of Chinese Materia Medica 2010;35(9):1145-1147
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the chemical constituents of Excoecaria acerifclia and their antitumor activities.
METHODThe constituents were isolated and purified by column chromatography. Their structures were identified by their physicochemical properties and spectral features. Cytotoxicities of the purified compounds were evaluated by MTI method against human cancer cell lines HepG2.
RESULTEight compounds were isolated and identified as: 7-hydroxy-6-methoxy-coumarin (1), 8-hydroxy-6,7-methoxy-coumarin (2), kaempferol (3), kaempferol-3-O-beta-D-glucoside (4), quercetin-3-O-beta-D galactoside (5), kaempferol-3-O-beta-D-glucoside-2"-gallate (6), beta-sitosterol (7), daucosterol (8).
CONCLUSIONAll compounds were isolated from this plant for the first time. Compounds 5 showed inhibitory activity towards HepG2 with IC50 values of 7.13 mol x L(-1).