Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure.
10.1007/s11596-016-1554-2
- Author:
Xing YANG
1
;
Rui HUANG
2
;
Yan-fang WANG
2
;
Xiao-yan LIANG
3
Author Information
1. Reproductive Medicine Centre, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510060, China. yxing_8358@126.com.
2. Reproductive Medicine Centre, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510060, China.
3. Reproductive Medicine Centre, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510060, China. lxyzy@263.net.
- Publication Type:Clinical Trial
- Keywords:
endometrium receptivity;
gonadotrophin-releasing hormone agonists;
idiopathic repeated implantation failure;
pituitary suppression
- MeSH:
Adult;
Embryo Implantation;
drug effects;
Embryo Transfer;
methods;
Female;
Gonadotropin-Releasing Hormone;
administration & dosage;
analogs & derivatives;
pharmacology;
therapeutic use;
Hormone Replacement Therapy;
methods;
Humans;
Pituitary Gland;
drug effects;
Pregnancy;
Sperm Injections, Intracytoplasmic;
methods
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(1):127-131
- CountryChina
- Language:English
-
Abstract:
Long-term gonadotropin-releasing hormone agonist (GnRHa) administration before in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in infertile women with endometriosis or adenomyosis significantly enhanced the chances of pregnancy in both fresh and frozen embryo transfer cycles. We hypothesized that long-term GnRHa treatment might also be beneficial for the idiopathic repeated implantation failure (RIF) patients. In the 21 patients receiving GnRHa and hormone replacement therapy (G-HRT) protocols for frozen embryo transfer, their data were compared with those of the 56 of frozen/fresh cycles they had previously undergone (previous protocols). Comparison showed that the finial results were significantly better with G-HRT protocols than with their previous protocols, with pregnancy rate, clinical pregnancy rate, implantation rate and on-going pregnancy rate being 70%, 60%, 40% and 38% respectively with G-HRT protocols, against 17%, 11%, 6.3% and 5% with previous protocols. The results showed that hormonally controlled endometrial preparation with prior GnRHa suppression could be used for patients who had experienced repeated failures of IVF treatment despite having morphologically optimal embryos, and the treatment may help increase the receptivity of the endometrium in these patients.
