Over-expression of Sox4 and β-catenin is associated with a less favorable prognosis of osteosarcoma.
10.1007/s11596-016-1565-z
- Author:
Zheng-Qi BAO
1
;
Chang-chun ZHANG
1
;
Yu-zhou XIAO
1
;
Jian-sheng ZHOU
1
;
Yi-sheng TAO
2
;
Da-min CHAI
3
Author Information
1. Department of Orthopaedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China.
2. Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China.
3. Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China. msautumn@163.com.
- Publication Type:Journal Article
- Keywords:
Sox4;
osteochondroma;
osteosarcoma;
prognosis;
β-catenin
- MeSH:
Adolescent;
Adult;
Biomarkers, Tumor;
genetics;
metabolism;
Bone Neoplasms;
metabolism;
pathology;
Case-Control Studies;
Child;
Female;
Humans;
Lung Neoplasms;
metabolism;
secondary;
Male;
Middle Aged;
Osteosarcoma;
metabolism;
pathology;
SOXC Transcription Factors;
genetics;
metabolism;
beta Catenin;
genetics;
metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(2):193-199
- CountryChina
- Language:English
-
Abstract:
The purpose of this study was to examine the association of the expression of Sox4 and β-catenin with the prognosis of osteosarcoma. A total of 108 cases of conventional osteosarcoma were involved in this study and 28 cases of osteochondroma served as controls. The expression of Sox4 and β-catenin was detected by using immunohistochemical staining and Western blotting. The results showed that Sox4 and β-catenin were over-expressed in 67 (62.03%) and 62 (57.41%) of 108 osteosarcoma cases, while in only 3 (10.71%) and 5 (17.86%) of 28 controls, respectively (P<0.05 for all). The expression of Sox4 and β-catenin was associated with the distant metastasis, pathological grade and Enneking stage of patients with osteosarcoma (P<0.05 for all). The mean overall survival time and the 5-year-survival rate in osteosarcoma patients with Sox4 and β-catenin over-expressed were significantly reduced as compared with those in Sox4 and β-catenin low-expression group (P<0.05 for all). Cox multifactor regression analysis revealed that the distant metastasis, Enneking stage, and the expression of Sox4 and β-catenin were independent risk factors of patients with osteosarcoma (P<0.05 for all). The findings indicated that overexpression of Sox4 and β-catenin is associated with a poor prognosis of osteosarcoma.
