High-density lipoprotein cholesterol and in-hospital mortality in patients with acute aortic dissection.
10.1007/s11596-016-1592-9
- Author:
Xin-Tian LIU
1
;
Xing-Wei HE
2
;
Rong TAN
1
;
Wan-Jun LIU
1
;
Bei WANG
1
;
Yu-Jian LIU
1
;
Tao WANG
1
;
Cheng-Wei LIU
2
;
Xi SU
2
;
He-Song ZENG
3
Author Information
1. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
2. Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan, 430022, China.
3. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. zenghs@tjh.tjmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
acute aortic dissection;
high-density lipoprotein cholesterol;
in-hospital mortality
- MeSH:
Acute Disease;
Adult;
Aged;
Alanine Transaminase;
blood;
Aneurysm, Dissecting;
blood;
diagnosis;
mortality;
pathology;
Aortic Aneurysm;
blood;
diagnosis;
mortality;
pathology;
Biomarkers;
blood;
Blood Glucose;
metabolism;
Blood Pressure;
Blood Urea Nitrogen;
Cholesterol, HDL;
blood;
Cholesterol, LDL;
blood;
Creatinine;
blood;
Female;
Hospital Mortality;
Humans;
Male;
Middle Aged;
Proportional Hazards Models;
Risk Factors;
Uric Acid;
blood
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(3):364-367
- CountryChina
- Language:English
-
Abstract:
The association between high-density lipoprotein cholesterol (HDL-C) and mortality in patients with acute aortic dissection (AAD) is unclear. From January 2007 to January 2014, a total of 928 consecutive AAD patients who were admitted within 48 h after the onset of symptoms were enrolled in the study. Patients were divided into two groups according to whether serum HDL-C level was below the normal lower limit or not. The Cox proportional hazard regression model was used to identify the predictive value of HDL-C for in-hospital mortality in patients with AAD. As compared with normal HDL-C group (n=585), low HDL-C group (n=343) had lower levels of systolic blood pressure and hemoglobin and higher levels of leukocyte, alanine aminotransferase, blood glucose, blood urea nitrogen, creatinine and urea acid. Low HDL-C group had significantly higher in-hospital mortality than normal HDL-C group (21.6% vs. 12.6%, log-rank=10.869, P=0.001). After adjustment for baseline variables including demographics and biologic data, the increased risk of in-hospital mortality in low HDL-C group was substantially attenuated and showed no significant difference (adjusted hazard ratio, 1.23; 95% confidence interval, 0.86-1.77; P=0.259). Low HDL-C is strongly but not independently associated with in-hospital mortality in patients with AAD.
