Tuberous sclerosis complex: Imaging characteristics in 11 cases and review of the literature.
10.1007/s11596-016-1632-5
- Author:
Shan HU
1
;
Dao-Yu HU
2
;
Wen-Zhen ZHU
3
;
Liang WANG
3
;
Zi WANG
3
Author Information
1. Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
2. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. cjr.hudaoyu@vip.163.com.
3. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- Publication Type:Case Reports
- Keywords:
computerized tomography;
magnetic resonance imaging;
tuberous sclerosis complex
- MeSH:
Adolescent;
Adult;
Brain;
diagnostic imaging;
pathology;
Child;
Child, Preschool;
Female;
Glioma, Subependymal;
diagnosis;
diagnostic imaging;
pathology;
Humans;
Lung;
diagnostic imaging;
pathology;
Magnetic Resonance Imaging;
methods;
Male;
Middle Aged;
Nervous System Diseases;
diagnosis;
diagnostic imaging;
pathology;
Tuberous Sclerosis;
classification;
diagnosis;
diagnostic imaging;
pathology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(4):601-606
- CountryChina
- Language:English
-
Abstract:
Tuberous sclerosis complex (TSC) is an uncommon multiorgan disorder that may present many and different manifestations on imaging. Radiology plays an important role in diagnosis and management, and can substantially improve the clinical outcome of TSC. Therefore, a comprehensive understanding of this disease is essential for the radiologist. The manifestations of TSC on computer tomography (CT) and magnetic resonance (MR) images were analyzed. Eleven patients with a clinical diagnosis of TSC were retrospectively reviewed. Central nervous system lesions included subependymal nodules (SENs) (11/11), subependymal giant cell astrocytomas (SEGAs) (2/11), cortical and subcortical tuber lesions (5/11), and white matter lesions (4/11). Of the 6 patients with abdominal scans, there were 6 cases of renal angiomyolipomas (AMLs), and one case of hepatic AMLs. Of the 4 patients undergoing chest CT, lung lymhangioleiomyomatosis (LAM) (2/4), and multiple small sclerotic bone lesions (2/4) were observed. Different modalities show different sensitivity to the lesion. Analysis of images should be integrated with patients' history in order to diagnose TSC.
