Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection.
- Author:
Liang-ping LU
1
;
Xing-wang LI
;
Ying LIU
;
Guo-chang SUN
;
Zhi-hai CHEN
;
Xi-lin ZHU
;
Quan-you HU
;
Hui LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alleles; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Haplotypes; Hepatitis B; genetics; Humans; Male; Middle Aged; Polymerase Chain Reaction
- From: Chinese Journal of Medical Genetics 2006;23(4):427-430
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of haplotype of HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection in Han population of north China.
METHODSTwo hundred and seven chronic hepatitis B (HB) patients, two hundred and twelve chronic asymptomatic hepatitis B virus (HBV) carriers (HBV carrier) and one hundred and forty-eight self-limited HBV infection were investigated for HLA-DRB1 and HLA-DQA1 alleles by sequence specific-polymerase chain reaction (PCR-SSP).
RESULTSThe frequency of DRB1*04-DQA1*0301 haplotype was 10.03% in self-limited HBV infection subjects, significantly higher than that in chronic HB patients (3.66%) (P=0.0005)ûthe frequency of DRB1*15/*16-DQA1*0102 haplotype was 6.80% in self-limited HBV infection subjects, significantly higher than 1.94% in chronic HB patients (P=0.0012) and 1.65% in asymptomatic HBV carriers (P=0.0004)ûwhile the frequency of DRB1*04-DQA1*0302 haplotype was 3.10% in chronic HB patients, higher than that in self-limited HBV infection subjects (0.39%) (P=0.0077).
CONCLUSIONIndividuals with different haplotypes composed of HLA-DRB1 and HLA-DQA1 might have different outcomes of HBV infection.
