An associated analysis of estrogen receptor 2 gene polymorphism linked with intrahepatic cholestasis of pregnancy.
- Author:
Li ZHANG
1
;
Shu-yun LIU
;
Qiang CHEN
;
Hai ZOU
;
Ya-qin ZUO
;
Xiao-hong XU
;
Yang-hui CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Cholestasis, Intrahepatic; genetics; Estrogen Receptor beta; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; Pregnancy; Pregnancy Complications; genetics
- From: Chinese Journal of Medical Genetics 2006;23(4):434-436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation ship of estrogen receptor 2 gene (ESR2) polymorphism associated with intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.
METHODSBy polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, the Rsa I polymorphism in exon 5 and the Alu I polymorphism in exon 8 of ESR2 were detected in 100 pregnant women with ICP (ICP group) and 100 normal pregnant women (control group) in Chengdu.
RESULTS(1) The frequency of the allele A of Alu I polymorphism in exon 8 was significantly higher in ICP group than in control group (P=0.031, OR=1.975), so did the frequency of the Aa+AA genotypes (P=0.028, OR=2.144). (2) The genotype distributions (rr, Rr and RR) and allele frequencies (r and R) of Rsa I polymorphism in exon 5 were not significantly different between the two groups (P>0.05).
CONCLUSIONThe Alu I polymorphism in exon 8 of ESR2 may be associated with the susceptibility of ICP in Chengdu. The Aa+AA genotype significantly elevated the risk suffering from the ICP. The Rsa I polymorphism in exon 5 of ESR2 is not associated with the risk getting the ICP in Chengdu.
