Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China.
- Author:
Yang CHEN
1
;
Jian-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; China; Gene Frequency; Genotype; HLA-B Antigens; genetics; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; genetics
- From: Chinese Journal of Medical Genetics 2006;23(4):461-462
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population.
METHODSThe technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population.
RESULTSThirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected.
CONCLUSIONThe HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.
