Genetic polymorphism of HLA-Cw locus in hematopoietic stem cell transplantation patient and donor population.
- Author:
Jin-feng LIU
1
;
Yu-ying SUN
;
Li JIN
;
Fei LIANG
;
Nan LIU
;
Fang YUAN
;
Yuan LUO
;
Shu-guang LIU
;
Xin-qiang SONG
;
Yong-zhi XI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alleles; Child; Child, Preschool; Female; Gene Frequency; HLA-C Antigens; genetics; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Tissue Donors; Young Adult
- From: Chinese Journal of Medical Genetics 2006;23(5):528-531
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the distribution of genes in HLA-Cw locus from Han population of China in a large scale, and to provide basic data for further study on the genetic characteristics of HLA-Cw locus of this population.
METHODSTotally 1285 unrelated Chinese Han individuals were typed by PCR-SSP, and statistics was utilized to investigate the distribution rules of detected genes.
RESULTSTwenty-three HLA-Cw alleles were identified in Chinese Han population, out of them HLA-Cw*01, *03, *07 and *08 were the commonest genes, which accounted for frequencies of 0.1529, 0.2385, 0.1747 and 0.1004, respectively. Five genes which could not be identified by serological method were deaed: HLA-Cw*12, *14, *15, *16 and *17. Hardy-Weinberg test showed that the observed genetic polymorphism distribution values were correspondent with the expected (chi-square=73.74, df=98, P>0.5).
CONCLUSIONThis study may serve a full-scale scientific genetic parameters of HLA-Cw genes for Chinese Han population studies.
