The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.
- Author:
Jun GAO
1
;
Hong-xia MA
;
Yan ZHOU
;
Zhi-bin HU
;
Xiang-jun ZHAI
;
Xue-chen WANG
;
Jian-wei QIN
;
Wen-sen CHEN
;
Guang-fu JIN
;
Ji-yong LIU
;
Xin-ru WANG
;
Yong-fei TAN
;
Qing-yi WEI
;
Hong-bing SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Breast Neoplasms; ethnology; genetics; Case-Control Studies; Cell Cycle Proteins; genetics; China; Female; Geminin; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2006;23(5):544-547
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer.
METHODSUsing polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population.
RESULTSNo significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR:1.16, 95% CI:0.88-1.54 for CDT1 GA+AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA+AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA+AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR:2.21, 95% CI:1.20-4.09).
CONCLUSIONThese findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.
