Association of genetic polymorphisms in human leukocyte antigen-DQA1 with intrahepatic cholestasis of pregnancy in Chengdu district.
- Author:
Bing PENG
1
;
Qiang CHEN
;
Li ZHANG
;
Hai ZOU
;
Shu-yun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Cholestasis, Intrahepatic; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; HLA-DQ Antigens; genetics; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Pregnancy; Pregnancy Complications; genetics
- From: Chinese Journal of Medical Genetics 2006;23(5):555-557
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between human leukocyte antigen-DQA1 (HLA-DQA1) allele gene polymorphism and intrahepatic cholestasis of pregnancy (ICP).
METHODSForty-five patients with ICP, eighteen ICP families, forty-five normal pregnant women and eighteen normal control families were tested for HLA-DQA1 allele gene polymorphism by polymerase chain reaction with sequence-specific primer (PCR-SSP) method.
RESULTSThe frequency of HLA-DQA1*0301 in normal pregnant women was markedly higher than that in the ICP group (P>0.05). No significant differences were observed between the frequencies of other detected HLA-DQA1 alleles in both groups. The analysis of feto-maternal or couples sharing of the HLA-DQA1 alleles showed that no significant differences were observed between the two groups.
CONCLUSIONThe above findings suggest that there is no significant association between the genetic polymorphisms in HLA-DQA1 and ICP in Chengdu district; HLA-DQA1*0301 may be a protective gene against ICP. It may prevent the development of ICP.
