OBJECTIVETo comprehend the Rh blood type distribution and the gene frequency in four main kinds of the minority nationalities in Guizhou, China, so as to supply a scientific foundation for guiding the prevention and cure against the Rh hemolysis illness.

METHODSThe irrelative individual blood of the four kinds of the minority nationalities (Miao, Buyi, Dong and Shui) in Guizhou was randomly collected in complete group style and the Rh blood type was identified and analyzed.

RESULTSTotally 15,992 minority nationality people were inspected and checked, and 4851 persons of Han nationality people were chosen as controls. Fifty-one persons were proven as Rh (D)negative individuals, in which, d gene frequency of Miao nationality population was 0.0474 and the Rh negative rate was 0.22%, d gene frequency of Buyi nationality population was 0.0602 and the Rh negative rate was 0.36%, d gene frequency of Dong nationality population was 0.0378 and the Rh negative rate was 0.14%, d gene frequency of Shui nationality population was 0.0307 and the Rh negative rate was 0.09%. d gene frequency of Han nationality population was 0.0574 and the Rh negative rate was 0.33%. In the four minority nationality populations, there was a common characteristic of the highest percentage of expressional type, CCDee type (52.47%-59.66%). At the same time, in the gene frequency of the four minority nationality populations, the CDe frequency was the highest: Miao nationality 0.7244, Buyi nationality 0.7389, Dong nationality 0.7410 and Shui nationality 0.7743.

CONCLUSIONThe Rh blood type distribution characteristic of the four minority nationality population, Miao, Dong, Buyi and Shui in Guizhou, is similar to that of the minority population in Southern China. The Rh negative rate of Miao, Dong and Shui nationality populations is lower than that of the Han nationality population(0.33%), only the Rh negative rate of Buiyi nationality population is closer or even higher than that of the Han nationality population. So that,the hemolysis illness frequency in the Rh newborn baby of Guizhou minority nationality population is not high.