ZNF217 gene was detected in ovarian serous cystadenocarcinoma by fluorescence in situ hybridization.
- Author:
Mei ZHONG
1
;
Jing LI
;
Yan-qing DING
;
Lan-lin SONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Cell Differentiation; Cell Line, Tumor; Cystadenocarcinoma, Serous; genetics; pathology; Cystadenoma, Serous; genetics; pathology; Female; Gene Amplification; Humans; In Situ Hybridization, Fluorescence; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; genetics; pathology; Survival Analysis; Trans-Activators; genetics
- From: Chinese Journal of Medical Genetics 2006;23(6):665-667
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate amplification of zinc finger protein 217 (ZNF217) gene in ovarian serous cystadenocarcinoma and its clinical significance.
METHODSTwenty three specimens of ovarian carcinoma, 10 specimens of ovarian benign tumors and 7 specimens of normal ovaries and two ovarian cancer cell lines, SKOV3 and HO-8910 were examined by fluorescence in situ hybridization (FISH).
RESULTSThe amplification of ZNF217 was gained in 12 case of ovarian cancers, there was only 1 case in ovarian benign tumor and not amplication in normal ovary.
CONCLUSIONThe amplification of ZNF217 is associated with ovarian cancer. Oncogenes ZNF217 maybe play a role in cell differentiation and indicate poorer survival in patients with ovarian cancer.
