Analysis the clinic and cytogenetics of myelodysplastic syndrome.
- Author:
Ling CEN
1
;
Min ZHOU
;
Ying-hao ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Female; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes; genetics; Prognosis
- From: Chinese Journal of Medical Genetics 2006;23(6):668-669
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analysis the relationship among cytogenetics, morphology and prognosis of the myelodysplastic syndrome (MDS) patients.
METHODSCytogenetics analysis of bone marrow cells was performed by direct method and/or 24 h culture method. The karyotype was analysed by R banding technique.
RESULTSOut of the 50 MDS patients, 22 were found with abnormal karyotype: two of them were +8, four of them were -7, four of them were 5q-, nine of them were 7q-, two of them were 20q- and one of them was 6q-. There are six patients had complex changes in chromosome.
CONCLUSION5q-, -7, 7q- are the most classic translocation in the MDS. The patients with 5q- have better prognosis and the patients with -7, 7q- have worse prognosis. Cytogenetics is very important in the MDS's diagnosis, progress and prognosis.
