Polymorphisms analysis of short tandem repeat loci D21S1433, D21S1442, D21S1444, D21S2051 in Guangdong Han nationality in China.
- Author:
Xin YANG
1
;
Can LIAO
;
Yi-ning HUANG
;
Yan LI
;
Cui-xing YI
;
Sao-qing WU
;
Ming PAN
;
Sun-yan HU
;
Si-ming YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genetics, Population; Heterozygote; Humans; Polymerase Chain Reaction; methods; Polymorphism, Genetic; Pregnancy; Tandem Repeat Sequences; genetics
- From: Chinese Journal of Medical Genetics 2006;23(6):689-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphic distribution of short tandem repeat (STR) sequences D21S1433, D21S1442, D21S1444, D21S2051 in Guangdong Han nationality in China.
METHODSUsing quantitative fluorescens PCR technology, the authors analyzed 200 unrelated samples to acknowledge the allele frequency, heterozygosity and other genetic information.
RESULTSD21S1433, D21S1442, D21S1444, D21S2051 were tested in 200 samples, which were tested to be statistical according to Hardy-Weinberg equilibrium (P> 0.05), 9, 10, 9 and 5 alleles were detected separately in each STRs. The heterozygosity of each STR was 0.818, 0.820, 0.770, and 0.261. The polymorphic information content > 0.7 in D21S1433, D21S1442, D21S1444, while D21S2051 owned only 0.247 polymorphic information.
CONCLUSIOND21S1433, D21S1442, D21S1444 are found to have high heterozygosity and polymorphic information content, and they could provide useful markers for genetic purposes, while D21S2051 is not informative in Guangdong Han nationality in China.
