Relationship between adiponectin receptor 1 gene -3881T/C variant and glucose metabolism in the Chinese.
- Author:
Cheng HU
1
;
Wei-ping JIA
;
Rong ZHANG
;
Cong-rong WANG
;
Qi-chen FANG
;
Xiao-jing MA
;
Jun-xi LU
;
Jing XU
;
Kun-san XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genotype; Glucose; metabolism; Humans; Insulin Resistance; genetics; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; genetics; Receptors, Adiponectin; genetics
- From: Chinese Journal of Medical Genetics 2007;24(1):27-30
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between adiponectin receptor 1 gene (ADIPOR1) single nucleotide polymorphism (SNP) and glucose metabolism and insulin resistance in the Chinese.
METHODSThe genotypes of -3881T/C of ADIPOR1 were determined through polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 664 Chinese in Shanghai. Among them, 370 were subjects with normal glucose tolerance and 294 were newly diagnosed diabetic patients without taking any drug. Phenotype measured were: height, weight to calculate body mass index; systolic blood pressure and diastolic blood pressure; plasma glucose level, serum insulin and C-peptide levels of blood obtained both at 0 and 120 minute during a standard 75-gram glucose oral glucose tolerance test. Insulin resistance and beta cell function were assessed by homeostasis model assessment (HOMA-IR and HOMA-B).
RESULTS(1) The frequencies of two alleles did not differ between the type 2 diabetic patients and ones with normal glucose tolerance (P is 0.6749). (2) The frequency of C allele is significantly lower in type 2 diabetic patients with insulin resistance compare with those without insulin resistance (P is 0.0121). (3) In type 2 diabetic patients, the C allele carriers had a significantly lower diastolic blood pressure (P is 0.0466) and HOMA-IR (P is 0.0498). (4) In subjects with normal glucose tolerance, the C allele carriers had a significantly lower fasting plasma glucose (P is 0.0140).
CONCLUSIONThese findings suggest that variant of ADIPOR1 plays a role in glucose metabolism and insulin resistance in the Chinese.