Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan.
- Author:
Hong-ying YANG
1
;
Li XUE
;
Mian XU
;
Chun-feng REN
;
Hui-yun YUAN
;
Wen-lin TAI
;
Yu YANG
;
Wei HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Base Sequence; China; Diabetes Mellitus, Type 2; genetics; Gene Frequency; Genetic Predisposition to Disease; genetics; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Male; Middle Aged; Molecular Sequence Data; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2007;24(1):101-103
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.
METHODSPolymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.
RESULTSHLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).
CONCLUSIONDR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.
