Optimization of dry granulating technique of Qibai Pingfei granule through response surface methodology.
- Author:
Xue-feng LI
;
Yun-xiao LI
;
Zhen-qiu XU
;
Jin MENG
;
Ming YAN
;
Rui-ting JIN
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
Powders;
Technology, Pharmaceutical;
methods
- From:
China Journal of Chinese Materia Medica
2015;40(15):2975-2978
- CountryChina
- Language:Chinese
-
Abstract:
To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows: lactose as excipient, dry extract powder to excipient at 1:2, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.
