Research progress of synthetic biology for tanshinones.
- Author:
Wei GAO
;
Tian-yuan HU
;
Juan GUO
;
Dong-mei LV
;
Zhu-bo DAI
;
Yong-jin ZHOU
;
Lu-qi HUANG
- Publication Type:Journal Article
- MeSH:
Diterpenes, Abietane;
biosynthesis;
Medicine, Chinese Traditional;
Salvia miltiorrhiza;
metabolism;
Synthetic Biology
- From:
China Journal of Chinese Materia Medica
2015;40(13):2486-2491
- CountryChina
- Language:English
-
Abstract:
Synthetic biology research methods which design and build a new artificial biological systems (medicinal plants or microorganisms system) with specific physiological functions through clarifying and simulating the basic law of the biosynthesis of active components of traditional Chinese medicine, is considered to be a potential method to produce an abundant resources of bioactive components. Tanshinones is a kind of diterpene quinone compounds with important pharmacological activities from traditional Chinese medicine Salvia miltiorrhiza. This article systematically introduced the research progress of the synthetic biology of S. miltiorrhiza, in order to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines, and give new research strategies for the sustainable development of traditional Chinese medicine resources.
