Function and mechanism of neurotensin (NTS) and its receptor 1 (NTSR1) in occurrence and development of tumors.
- Author:
Huan-rong HU
;
Zhen DONG
;
Liang YI
;
Xiao-yan HE
;
Yan-li ZHANG
;
Ya-ling LIU
;
Hong-juan CUI
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Medicine, Chinese Traditional;
Neoplasms;
etiology;
Neurotensin;
chemistry;
physiology;
Receptor, Epidermal Growth Factor;
physiology;
Receptors, Neurotensin;
chemistry;
physiology;
Signal Transduction;
physiology;
rhoA GTP-Binding Protein;
physiology
- From:
China Journal of Chinese Materia Medica
2015;40(13):2524-2536
- CountryChina
- Language:English
-
Abstract:
As a neuropeptide, neurotensin (NTS) is widely expressed in central and peripheral nervous system, which is mainly mediated byneurotensin receptor1 (NTSR1) to activate the related downstream signaling pathways. After summarized the function and mechanism of NTS/NTSR1 in various malignant tumors, we found that NTS/NTSR1 played essential roles during tumor initiation and development. NTS/NTSR1 regulates tumor initiation, proliferation, apoptosis, metastasis and differentiation mainly through three pathways, including IP3/Ca2+ /PKC/MAPKs pathway, MMPs/EGFR/MAPKs (PI3K/Akt) pathway, or Rho-GTPsaes and non-receptor tyrosine kinase pathway. Besides, NTS/NTSR1 is also regulated by some upstream pathways and some traditional Chinese medicine preparations and traditional Chinese medicine therapies. In this article, we summarized the function of NTS/NTSR1 and its mechanisms, and discussed the prospective in its application to clinical diagnosis and drugs targeting.
