A Case of Subcutaneous Panniculitic T-cell Lymphoma-like Lesion Occurring in a Patient with Systemic Lupus Erythematosus.
- Author:
Jae Wang KIM
1
;
Sang Seok KIM
Author Information
1. Department of Dermatology, College of Medicine, Cheju National University, Jeju, Korea. rulidroxim@hanmail.net
- Publication Type:Case Report
- Keywords:
Subcutaneous panniculitic T-cell lymphoma;
Systemic lupus erythematosus
- MeSH:
Arm;
Cytophagocytosis;
Diagnosis;
Eosinophils;
Fat Necrosis;
Female;
Genes, T-Cell Receptor;
Humans;
Lupus Erythematosus, Systemic*;
Lymphohistiocytosis, Hemophagocytic;
Lymphoma, T-Cell;
Middle Aged;
Panniculitis, Lupus Erythematosus;
T-Lymphocytes*
- From:Korean Journal of Dermatology
2005;43(9):1241-1246
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Subcutaneous panniculitic T-cell lymphoma and lupus panniculitis may present histologic similarities, including lobular lymphocytic infiltrate, eosinophilic fat necrosis, histiocytic cytophagocytosis, lymphocytic angioinvasion and lymphocytic atypia. The observation that lupus panniculitis precedes or coincides with subcutaneous panniculitic T-cell lymphoma can make the diagnosis even more enigmatic. We describe a case of a 46-year old woman who presented with multiple infiltrative nodules on her arm. Her medical history of ongoing systemic lupus erythematosus favored a presumptive diagnosis of lupus panniculitis. However, the histopathologic examination, immunohistochemical study and T-cell receptor gene analysis revealed subcutaneous panniculitic T-cell lymphoma with hemophagocytic syndrome.
