The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication
- Author:
Xue CHEN
1
;
Zhixiang LIU
;
Qing YUE
;
Houjun LIU
;
Yan WU
;
Jiawen LI
Author Information
1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan. 430022. China
- Keywords:
TNF-α;
ICAM-1;
lichen planus
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2007;27(6):739-741
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistechemistty was used to detect the expression of TNF-α and ICAM-1 in skin le- sions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the in- crease of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.
