Protective Effects of Overexpression of bcl-xl Gene on Local Cerebral Infarction in Transgenic Mice Undergoing Permanent Occlusion of Middle Cerebral Artery
- Author:
WANG FURONG
1
;
JIANG YONGSHENG
;
ZHANG SUMING
;
XIAO WENWU
;
ZHU SUIQIANG
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
bcl-xl gene;
transgenic mice;
cerebral infarction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the protective effects of the overexpression of bcl-xl gene on local cerebral infarction in the transgenic mice subject to permanent occlusion of middle cerebral artery, the models of bcl-xl transgenic mice were established and subjected to cerebral infarction by intralu- minal occlusion of the middle cerebral artery. The infarct volume and the neurological scores were observed and comparison between the wild type mice and the transgenic mice was made. It was found that the infarct volume and the neurological scores in the transgenic mice were significantly decreased as compared with those in the wild type mice. It was suggested that the overexpression of bcl-xl gene in transgenic mice could reduce the infarct volume and improve the neurological function of the mice.
