Expression and Prognostic Significance of Livin in the Progression of Bladder Cancer
- Author:
ZHU ZHAOHUI
1
;
WANG YANBO
;
DING XIAOBO
;
ZENG FUQING
;
XU KAI
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
Livin;
bladder cancer;
real-time quantitative PCR;
immunohistochemistry
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(1):90-92
- CountryChina
- Language:Chinese
-
Abstract:
It has been suggested that progression of bladder transitional cell cancer (BTCC) may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Re- cently Livin, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where its expression is suggested to have clinical significance. In order to explore the significance of Livin expression in the development of BTCC, immunohistochemistry and RT-QPCR were used to detect the expression of Livin mRNA in tumor tissues and adjacent normal tissues of 30 cases of BTCC. The results showed that the positive rate of Livin expression in adjacent normal tissues and tumor tissues was 0 and 60% (18/30) respectively. The -△△CT value of Livin in BTCC tissues was 8.0454 (7.4264-8.6644) times of that in adjacent normal tissues. The expression of Livin mRNA had no correlation with tumor pathological grades and clinical stages. It was sug- gested that there was weak expression ? Livin mRNA in adjacent normal tissues, but strong in tumor tissues.
