Selective Expression of Progesterone Receptor in Malignant Melanoma Was Inversely Correlated with PCNA
- Author:
LI JIAWEN
1
;
FANG XIANFENG
;
CHEN XU'E
;
CHEN JING
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
malignant melanoma;
progesterone receptor
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(2):216-218
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the role of progesterone receptor (PR) expression in malignant melanoma (MM), PR and proliferative cell nuclear antigen (PCNA) expression were immunohistochemistri- tally evaluated in a series of 35 specimens of MM, and the correlation between the immunohisto- chemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% (9/35) of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression (r=-0.353, P=0.026). PR expression was slightly in- creased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of pro- gesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.
