Up-regulation of Human Leukocyte Antigen G Expression in Primary Cutaneous Malignant Melanoma Associated with Host-vs-tumor Immune Response
- Author:
FANG XIANFENG
1
;
ZHANG XUXIN
;
LI JIAWEN
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
cutaneous malignant melanoma;
human leukocyte antigen G
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(2):219-221
- CountryChina
- Language:Chinese
-
Abstract:
Human leukocyte antigen G (HLA-G) is one of the molecules implicated in immunotolerance. To investigate the role of HLA-G in primary cutaneous malignant melanoma (CMM), a series of 47 skin melanocytic lesions were immunohistochemicaily evaluated. The correlation between HLA-G expression and CMM clinicohistopahtologicai data and Bcl-2 expression was also analyzed.HLA-G expression was detected in a variety of cell types. No significant difference in HLA-G expression was observed between malignant and non-malignant melanocytic lesions. HLA-G expres- sion was significantly correlated with the inflammatory infiltration and Bel-2 expression, whereas no significant correlation with ulceration, tumor thickness, clinical stage, histopathologicai subtypes were observed. HLA-G expression may be the result of host immune reaction in tumor microenvi- ronment rather than a malignant feature of CMM.
