Expression of Apoptosis Related Protein in Skin Lesions of Lichen Planus and Its Implication
- Author:
CHEN XU'E
1
;
WU YAN
;
LI JIAWEN
;
LIU ZHIXIANG
;
YUE QING
;
LIU HOUJUN
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
Caspase-3;
Bax;
lichen planus
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(3):349-351
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.
