Experimental study on hemostatic effect of flos sophorae and its extracts.
- Author:
Hui LI
1
;
Gui-dong YUAN
;
Ya-hong JIN
;
Raorao LI
;
Lan WANG
;
Sufen WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bleeding Time; Blood Coagulation; drug effects; Capillary Permeability; drug effects; Drugs, Chinese Herbal; chemistry; pharmacology; Female; Flowers; chemistry; Hemostatics; pharmacology; Male; Mice; Quercetin; isolation & purification; pharmacology; Rats; Rats, Wistar; Rutin; isolation & purification; pharmacology; Sophora; chemistry; Tannins; isolation & purification; pharmacology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(11):1007-1009
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the hemostatic effect of Flos Sophorae in crude, parched and carbonized forms and its extracts, including rutin, quercetin and tannin.
METHODSAll the testing samples were orally administered to the experimental animals for 5 days, then the bleeding time (BT), coagulation time (CT), platelet count and capillary permeability (CP) in the treated mice were tested, and the prothrombin time (PT), fibrinogen (FBG) content and platelet aggregation rate (PAR) in the treated rats were determined.
RESULTSAll the samples could lower the CP, BT and CT in mice and also decrease the plasma PT in rats. All three forms of Flos Sophorae could increase FBG in rats, while the three extracts of it could inhibit the PAR in rats obviously. In addition, rutin had the effect of raising the platelet count.
CONCLUSIONAll the three forms and three extracts of Flos Sophorae have hemostatic effect, the effect of parched and carbonized form is higher than that of crude drug. The mechanism of the hemostatic effect of the six kinds of sample might be various.
