Change of peripheral blood monocytes derived macrophage scavenger receptors activity in patients with coronary heart disease, and the intervention effect of ginkgo biloba extract.
- Author:
Gui-Yue ZHU
1
;
Xing-Lei ZHU
;
Qing-Xin GENG
;
Xinghua ZHANG
;
Jianhua SHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angina Pectoris; blood; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Ginkgo biloba; chemistry; Humans; Intercellular Adhesion Molecule-1; blood; Male; Middle Aged; Monocytes; metabolism; Myocardial Infarction; blood; drug therapy; Phytotherapy; Receptors, Immunologic; blood; Receptors, Scavenger; Vascular Cell Adhesion Molecule-1; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(12):1069-1072
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the activity of peripheral blood monocytes (PBMs) derived macrophage scavenger receptors (MSR) and changes of serum inflammatory factor in peripheral blood in patients with coronary heart disease (CHD), and to evaluate the effect of Ginkgo biloba extract (GBE) on the MSR activity, to explore the relationship between inflammatory factor and scavenger receptors activity as well as the possible mechanism of GBE in stabilizing the atheromatous plaque.
METHODSNinety-seven CHD patients with normal blood lipids were classified into the stable angina group, the unstable angina group and the acute myocardial infarction group, and 29 healthy persons were taken as control. Levels of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in all subjects were determined. And their PBMs were isolated, cultured in vitro, and transferred into macrophage to observe the effect of GBE on the expression of scavenger receptors.
RESULTSThe levels of MSR activity, CRP, sICAM-1 and sVCAM-1 in patients with acute myocardial infarction > unstable angina > stable angina > control.
CONCLUSIONGBE could down-regulate the MSR activity in CHD patients, which was positively correlated with levels of CRP, sICAM-1 and sVCAM-1. MSR activity could be taken as a monitoring criteria for active degree of vulnerable atherosclerosis plaque. GBE has the effect of suppressing MSR activity.