Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs.
- Author:
Yun SUN
1
;
Feng XU
;
Hong-Quan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Asthmatic Agents; pharmacology; Asthma; blood; chemically induced; Bronchoalveolar Lavage Fluid; cytology; Coumaric Acids; pharmacology; Endothelin-1; blood; Eosinophils; pathology; Female; Guinea Pigs; Male; Nitric Oxide; blood; Ovalbumin
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(12):1103-1105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-asthmatic effect of sodium ferulate (SF) and its mechanism in guinea pig asthmatic model.
METHODSGuinea pigs were sensitized with ovalbumin as animal asthmatic model and treated with 3 different concentration of SF for 8 days. Levels of endothelin (ET) and nitric oxide (NO) in blood and lung tissue, and eosinophil (EOS) in blood and bronchoalveolar lavage fluid (BLAF) was counted at the end of trial.
RESULTSSF could significantly lower the ET content and increase the NO concentration in serum and lung tissue, reduce the number of EOS in blood and BLAF (P < 0.05, P < 0.01). Stronger effect was showed in the high dose group.
CONCLUSIONMechanism of anti-asthmatic action of SF might be to increase NO concentration, lower ET content, alleviate EOS infiltration.
