Relationship between CD8+ T-cell CD28 expression and TCM differentiation type in patients with chronic aplastic anemia.
- Author:
Ting DENG
1
;
Yun-lu WANG
;
Qi HU
;
Si-ming SUN
;
Xiao-ying ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Anemia, Aplastic; classification; diagnosis; immunology; CD28 Antigens; biosynthesis; CD8-Positive T-Lymphocytes; immunology; Chronic Disease; Diagnosis, Differential; Humans; Kidney Diseases; immunology; Male; Medicine, Chinese Traditional; Yang Deficiency; immunology; Yin Deficiency; immunology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(1):16-18
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between CD8+ T-cell CD28 molecular expression in peripheral blood and TCM type in patients with chronic aplastic anemia (CAA).
METHODSUsing flow cytometry to detect the CD28 expression in 45 in-patients or out-patients and 24 healthy subjects for control. And the relation with TCM type was analyzed from the immunological aspect.
RESULTS(1) The levels of CD8, CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- were all higher in the CAA patients than those in the healthy subjects (P < 0.05 or P < 0.01). (2) The levels of CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- were all higher in the CAA patients of Shen-Yin deficiency type than those in the CAA patients of Shen-Yang deficiency type (P < 0.05 or P < 0.01).
CONCLUSION(1) The abnormal high expression of peripheral blood co-stimulatory molecules CD28 suggested CD28 disorder may play an important role in immuno-pathogenesis of CAA. (2) The levels of peripheral CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- can be taken as an objective indexes for TCM typing of CAA, which was disordered more severe in patients of Shen-Yin deficiency type than in those of Shen-Yang deficiency type.
