Effect of compound shenhua tablet on macrophage migration inhibition factor in renal tissue of 5/6 nephrectomized rats.
- Author:
Jian-jun LI
1
;
Xiang-mei CHEN
;
Yue GU
;
Ri-bao WEI
;
Jing DU
;
Suo-zhu SHI
;
Zhong YI
Author Information
- Publication Type:Journal Article
- MeSH: Albuminuria; blood; Animals; Creatinine; blood; Drugs, Chinese Herbal; pharmacology; Fibrosis; pathology; Kidney; metabolism; pathology; Macrophage Migration-Inhibitory Factors; metabolism; Male; Nephrectomy; Rats; Rats, Wistar; Tablets
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of compound shenhua tablet (CST) on the residual kidney expressed macrophage migration inhibition factor (MIF) in rats.
METHODSCST was used to treat 5/6 nephrectomized rats for 12 weeks and the conditions of blood pressure, urinary protein, blood biochemical indices (creatinine, blood urea nitrogen), kidney pathologic change and MIF expression were observed.
RESULTSCST could significantly lower the serum levels of creatinine (P < 0.05), and 24 hrs urinary protein (P < 0.01), reduce the MIF expression and macrophage infiltration in renal glomerulus and tubular mesenchym, and lower the degree of renal glomerular sclerosis and interstitial fibrosis.
CONCLUSIONThe inhibition on the highly expressed MIF may be an important mechanism of the drug in restraining chronic inflammation in residual kidney, delaying the sclerosis and fibrosis progression and protecting renal function.
