Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction.
- Author:
Li-zhong XIAO
1
;
Ling-jun GAO
;
Shao-chun MA
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; Antigens, CD34; metabolism; Drug Therapy, Combination; Female; Granulocyte-Macrophage Colony-Stimulating Factor; therapeutic use; Humans; Interleukin-6; blood; Isoflavones; therapeutic use; Male; Matrix Metalloproteinase 9; blood; Middle Aged; Myocardial Infarction; drug therapy; Phytotherapy; Recombinant Proteins; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the effects of puerarin and granulocyte colony-stimulating factor (G-CSF) in treating acute myocardial infarction (AMI) and on the size of infarcted area and cytokines.
METHODSSeventy-nine patients with anterior AMI were randomly divided into three groups, they were treated with conventional Western medical treatment, but to the puerarin group (PG) and the G-CSF group (GCG) puerarin and G-CSF was given additionally, respectively. The infarcted size, plasma G-CSF, matrix metalloproteinase-9 (MMP-9), serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were detected before and after treatment.
RESULTSThe infarcted size was positively correlated to the levels of G-CSF, MMP-9, IL-6 and TNF-alpha before treatment ( r = 0.45, 0.42, 0.44 and 0.42, P<0.01 ). The infarcted size in the PG and the GCG decreased on the 28th day (P<0.01), the level of G-CSF, MMP-9, IL-6 and TNF-alpha in the PG on the 7th day all decreased (P<0.05), but these indexes in the GCG increased (P<0.05), while those in the control group were unchanged (P>0.05).
CONCLUSIONPuerarin and G-CSF are effective in decreasing infarcted size, but their effects on cytokines are different entirely.
