Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome.
- Author:
Guo-Hua HU
1
;
Zhu-Wen YI
;
Jing-He WANG
;
Jing-Chan YAO
Author Information
- Publication Type:Journal Article
- MeSH: Child; Drugs, Chinese Herbal; pharmacology; Female; Glycosides; pharmacology; Humans; Interleukin-12; metabolism; Interleukin-13; metabolism; Interleukin-2; metabolism; Interleukin-4; metabolism; Male; Nephrotic Syndrome; drug therapy; metabolism; Th1 Cells; drug effects; metabolism; Th2 Cells; drug effects; metabolism; Tripterygium; chemistry; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(4):441-443
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome.
METHODPatients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg x kg(-1) x d(-1) orally tid for 12 weeks. However, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-alpha, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy.
RESULTIn treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12.
CONCLUSIONTriptergium wilfordii polyglycosidium could reduce the cytokine level (except for IL-12) of Th1 and Th2, which could lead a therapeutic effect of in the child patients of RNS.
