Chemical constituents from stems of Schisandra propinqua.
- Author:
Li-Jia XU
1
;
Hai-Tao LIU
;
Yong PENG
;
Wei XIAO
;
Shi-Lin CHEN
;
Si-Bao CHEN
;
Pei-Gen XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Furans; chemistry; Lignans; chemistry; Magnetic Resonance Spectroscopy; Plant Stems; chemistry; Plants, Medicinal; chemistry; Schisandra; chemistry; Spectrometry, Mass, Electrospray Ionization
- From: China Journal of Chinese Materia Medica 2008;33(5):521-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in the stems of Schisandra propinqua and evaluate their effects on proliferation of vascular smooth muscle cells (VSMCs) in vitro by MTT assay.
METHODThe compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis (ESI-MS, 1H-NMR, 13C-NMR).
RESULTFive compounds were isolated and identified as galgravin (1), veraguensin (2), octadecanoic acid 2, 3-dihydroxypropyl ester (3), hexadecanoic acid 2, 3-dihydroxypropy ester (4), tetracosanoic acid 2, 3-dihydroxypropyl ester (5).
CONCLUSIONAll the compounds were isolated for the first time from the plant. 1, 2, 5 showed inhibiting effects on vascular smooth muscle cell (VSMCs) proliferation in vitro.
