Experimental study of Solanum nigrum on inhibiting angiogenesis in chick chorioallantoic membrane.
- Author:
Yang XU
1
;
Rui-Le PAN
;
Qi CHANG
;
Meng QIN
;
Yan LIU
;
Jin-Tian TANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chick Embryo; Chickens; Chorioallantoic Membrane; blood supply; drug effects; Drugs, Chinese Herbal; pharmacology; Neovascularization, Physiologic; drug effects; Plant Extracts; pharmacology; Solanum nigrum; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(5):549-552
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the inhibitory effect of Solanum nigrum on angiogenesis.
METHODWe examined the effects of S. nigrum on angiogenesis in the chick chorioallantoic membrane (CAM) model. On day 7 of chick embryo incubation, three concentrations of S. nigrum aqueous extracts were applied to CAMs, and their effects were evaluated on day 9.
RESULTThe angiogenesis area was significantly smaller in the CAM treated with S. nigrum than that in the control group (P < 0.001). Pathology analysis indicated that less angiogenesis occurred in the tissue of CAM under the filter paper treated with S. nigrum and the structure of large arteries was destroyed. The surrounding CAM showed a few angiogenesis formation. However, in the control group, a number of angiogenesis were observed.
CONCLUSIONS. nigrum could inhibit the angiogenesis on CAM.
