A review on liquid-filled hard gelatin capsules.
- Author:
Jia-Hua MA
1
;
Ming YANG
;
Min ZENG
;
Xue-Mei CHEN
;
Jie LAN
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China. jiahuama@163.com
- Publication Type:Journal Article
- MeSH:
Capsules;
chemistry;
Drug Delivery Systems;
Drugs, Chinese Herbal;
Gelatin;
chemistry
- From:
China Journal of Chinese Materia Medica
2008;33(5):602-605
- CountryChina
- Language:Chinese
-
Abstract:
Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which adopt gelatin or the hydroxypropyl methyl cellulose (HPMC) as capsule shell. The liquid-filled hard gelatin capsule is increasingly getting attention because of its new-concept dosage form design, which deliver liquid drugs by solid form. The paper mainly introduces application, pharmaceutical manufacturing, quality assessment, prospect of liquid-filled hard gelatin capsules, and focuses on the application and pharmaceutical manufacturing (preparation) of liquid-filled capsule. It is suggested that the capsule is suitable for various liquid or semi-solid natural plant extract and achieve different release profiles. The preparation adopted liquid-filled hard capsules technology. The influence factors concluded property of shell and device of filling. The quality was often evaluated by moisture content of capsule shell, dissolution rate etc. At the same time, it was pointed out that the new dosage form has remarkable marketing prospect and bring profits for enterprises.
