Influence of borneol on nasal absorption of Ligustrazinee.
- Author:
Yu-De LIU
1
;
Han-Jin SUN
;
Rong LI
;
Wei WU
;
Hong-Gui CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biological Transport; drug effects; Bornanes; pharmacology; Drug Administration Routes; Female; Kinetics; Male; Nose; drug effects; metabolism; Pyrazines; administration & dosage; pharmacokinetics; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2008;33(3):259-261
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the influence of borneol on nasal absorption enhancement of ligustrazine.
METHODThe rats were randomly divided into 3 groups: Xiongbing nasal spray group (group A), Chuanxiong nasal spray group (group B) and Xiongbing group by decoction intragastric administration (group C). All the rats were decapitated at several time points after administration. The whole brains of rats were taken to homogenate and detected the concentrations of ligustrazine.
RESULTCompared with group B and C, group A has its characteristics: quick absorption, quick distribution and quick excretion of ligustrazine.
CONCLUSIONNasal administration is a quick-acting way for ischemic cerebral vessel insufficientia. Borneol promoted nasal absorption of ligustrazine into brain.
