Influence of Tinglizi on collagen volume fraction and perivascular collagen area in left ventricle tissue of cardiac hypertrophy induced by abdominal aortic banding in rats.
- Author:
Juan GUO
1
;
Chang-Xun CHEN
;
Wei-Liang GU
;
Jun DU
;
Yun-Hui SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Pressure; drug effects; Cardiomegaly; drug therapy; Drugs, Chinese Herbal; pharmacology; Heart Rate; drug effects; Heart Ventricles; drug effects; Male; Rats; Rats, Sprague-Dawley; Ventricular Remodeling; drug effects
- From: China Journal of Chinese Materia Medica 2008;33(3):284-287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the influence of Tinglizi on collagen volume fraction (CVF) and perivascular collagen volume area (PVCA ) in left ventricle tissue of cardiac hypertrophy induced by abdominal aortic banding in rats.
METHODVentricular remodeling was induced by abdominal aortic banding (AAB) in rats. After 30 day treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP); heart rate (HR) were measured. The histological assay consisted of the HE stain for determining the myo-cardium cell cross section and collagen stain (Van Gieson' method) for determining collagen content, including collagen volume fracton (CVF) and perivascular collagen volume area (PVCA).
RESULTThe experimental data demonstrated that Tinglizi decreased SBP, DBP, HR and could significantly reduce the total collagen content (CVF, PVCA) and lessen the myocardium cell cross section (P < 0.05).
CONCLUSIONTinglizi may decrease the total collagen content of ventricle and attenuate the ventricular remodeling induced by abdominal aortic banding.
