Study on preventing effects of procyanidins on selenite cataract development in rats.
- Author:
Xuan CHENG
1
;
Wei-Bo CHENG
;
Hao YAN
;
Su-Cai ZHANG
;
Yu WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cataract; chemically induced; prevention & control; Female; Glutathione Peroxidase; metabolism; Male; Malondialdehyde; metabolism; Proanthocyanidins; therapeutic use; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Selenite; pharmacology; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(3):300-302
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preventing effects of procyanidins (PC) on selenite cataract in rats and the time-effect relationship.
METHODForty five SD rats were divided into three groups: control, model and experiment groups. The rats in the experiment group were fed additionally with the PC by 80 mg x kg(-1) when they were supplied the equal selenite with the model group. Five rats of each group were regularly sacrificed by bleeding from femoral artery at sixth, eleventh, sixteenth day and the level of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of all lenses was measured.
RESULTCompared with the model group, the level of the MDA in the experiment group at the eleventh day and the sixteenth day greatly decreased (P < 0.01). At the sixteenth day the level of the SOD and GSH-Px had an increase (P < 0.01), which showed its anti-oxygenation.
CONCLUSIONPC indicated the obvious inhibition in the development of the rat cataract. The treatment period was recommended at least for fifteen days.
