Antidepressant effect of acute administration with Jianyate Hao (JYTH) and its possible mechanism.
- Author:
Ping LV
1
;
Shan LI
;
Ren-Ye WANG
;
Liang CHEN
;
Bao-Shan KU
;
Jian-Chun PAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antidepressive Agents; pharmacology; therapeutic use; Behavior, Animal; drug effects; Brain; drug effects; metabolism; Depression; drug therapy; metabolism; Drugs, Chinese Herbal; pharmacology; therapeutic use; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(3):307-310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEJianyate Hao (JYTH) , a traditional Chinese medicine formula, which has been used effectively to treat depression in the past ten years. The purpose of this study was to explore the antidepressant effect of acute administration with JYTH and its possible mechanism.
METHODthe animals behavioral despair models of depression, the tail suspension and forced swimming tests, were used to explore the antidepressant effects of JYTH. In addition, the locomotor activity test was used to detect the change of locomotor activity. The monoamine oxidase activity in the mouse brain was also determined by using fluorospectrophotometry.
RESULTJYTH (17.5, 35, 70 g x kg(-1), ig) could decrease the duration of immobility in both tail suspension and forced swimming tests, and the effect of JYTH (35 g x kg(-1) ig) was resembling imipramine (10 mg x kg(-1), ip) in relieving depression. And the effective doses (17.5, 35, 70 g x kg(-1), ig) did not alter locomotion activity. Moreover, JYTH (35 g x kg(-1), ig) was found to inhibit monoamine oxidase activity in the mouse brain.
CONCLUSIONThese findings suggest that JYTH exerts antidepressant effect in animals behavioral despair tests and the underlying mechamism may involve the inhibition monoamine oxidase activity in the mouse brain.
