Quality comparison of Hirudo before and after processed by French chalk.

Author: Yong-Tai ZHANG ¹
Author Information

1. College of Chinese Herb, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. analysisdrug@126.com
Publication Type:Journal Article
MeSH: Animals; Blood Circulation; drug effects; Ethanol; chemistry; Hirudins; analysis; Hirudo medicinalis; chemistry; Hypoxanthine; analysis; Menstrual Cycle; drug effects; Solubility; Water; chemistry
From: China Journal of Chinese Materia Medica 2008;33(7):766-768
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo evaluate the effects of processing methods of Hirudo.
METHODBoth water and alcohol extracts of Hirudo were studied according to Chinese Pharmacopeia (Edition 2005). The content of hypoxanthine in Hirudo was measured by high performance liquid chromatography (HPLC) and Hirudin was determined by thrombin.
RESULTThe contents of water, water soluble extraction, ethanol soluble extraction and hirudin in crude Hirudo are higher than those in processed Hirudo. But the contents of hypoxanthine in processed Hirudo is higher than in crude Hirudo.
CONCLUSIONHirudo fried by French chalk can decrease the active components with high intensive drug property, accordingly the toxicity of Hirudo was decreased. As a result, the effects of Hirudo as invigorate the circulation of blood and stimulate the menstrual flow were abated.